Anti-Beta-Arrestin 1 antibody
Specifications
| Product Cat#: | AB-06-0507 |
| Product type: | Primary antibody |
| Antigen: | Beta-Arrestin 1 |
| Immunogen: | A region surrounding Ser 86 to Thr 98 of β-Arrestin-1 of human origin. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:100-1:1000); Immunoprecipitation (1-2 μg per 100-500 μg of total protein) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal, 4G6 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified/Antigen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ARB1 antibody |
| ARR1 antibody | |
| ARRB1 antibody | |
| ARRB1_HUMAN antibody | |
| Arrestin 2 antibody | |
| Arrestin beta 1 antibody | |
| Arrestin beta-1 antibody | |
| Beta-arrestin-1 antibody |
Target information
The members of the G protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. Members of the β-Arrestin family regulate receptor binding to G proteins. β-Arrestins have been found to be located at postsynaptic sites, where they are thought to act in concert with βARK (βARK1, also designated GRK 2, or βARK2, also designated GRK 3) to regulate G protein-coupled neurotransmitter receptors. Expression of β-Arrestin-1 and β-Arrestin-2 is seen predominantly in spleen and neuronal tissues. It has been shown that β-Arrestin-1 expression is modulated by intracellular cAMP, which may be a novel mechanism for the regulation of receptor-mediated responses.
Provider
Erpantech Laboratory