Anti-BCR antibody
Specifications
| Product Cat#: | AB-06-0487 |
| Product type: | Primary antibody |
| Antigen: | BCR |
| Immunogen: | Purified recombinant fragment of human BCR expressed in E. Coli |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:2000); Flow Cytometry (1:40-1:100) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal, G12-E11 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified/Antigen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ALL antibody |
| Bcr antibody | |
| BCR/ABL FUSION GENE, INCLUDED antibody | |
| BCR/FGFR1 chimera protein antibody | |
| BCR/FGFR1 FUSION GENE, INCLUDED antibody | |
| BCR/PDGFRA FUSION GENE, INCLUDED antibody | |
| BCR_HUMAN antibody | |
| BCR1 antibody | |
| Breakpoint cluster region antibody | |
| Breakpoint cluster region protein antibody | |
| CML antibody | |
| D22S11 antibody | |
| D22S662 antibody | |
| FGFR1/BCR chimera protein antibody | |
| PHL antibody | |
| Renal carcinoma antigen NY-REN-26 antibody |
Target information
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation.
Provider
Erpantech Laboratory
