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Anti-Bcl-6 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-0484
Anti-Bcl-6 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-0484
Product type: Primary antibody
Antigen: Bcl-6
Immunogen: Recombinant protein
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:400-1:2000)
Reactivity: Mouse, Human
Clonality (clone number): Monoclonal, JB18-48
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3.
Concentration: 1 mg/ml
Purity: Protein A/G affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: B Cell Lymphoma 6 Protein antibody
B-cell CLL/lymphoma 6 antibody
B-cell lymphoma 5 protein antibody
B-cell lymphoma 6 protein transcript antibody
BCL5 antibody
BCL6A antibody
Cys-his2 zinc finger transcription factor antibody
LAZ3 antibody
Lymphoma-associated zinc finger gene on chromosome 3 antibody
Protein LAZ-3 antibody
ZBTB27 antibody
Zinc finger and BTB domain-containing protein 27 antibody
Zinc Finger Protein 51 antibody
Zinc finger transcription factor BCL6S antibody
ZNF51 antibody
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Target information

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5′-TTCCTAGAA-3′ (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4+ T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

Provider

Erpantech Laboratory

Download

MSDS-AB-06-0484.pdf (130 downloads )