Anti-BAFF antibody
Specifications
| Product Cat#: | AB-06-0450 |
| Product type: | Primary antibody |
| Antigen: | BAFF |
| Immunogen: | Purified recombinant fragment of human BAFF expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:2000); Immunocytochemistry (1:100-1:500); Flow Cytometry (1:100-1:200) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal, A2-C3 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | B cell activating factor receptor antibody |
| B-cell-activating factor receptor antibody | |
| BAFF R antibody | |
| BAFF receptor antibody | |
| BAFF-R antibody | |
| BAFFR antibody | |
| BLyS receptor 3 antibody | |
| BlySR3 antibody | |
| BR 3 antibody | |
| BR3 antibody | |
| BROMIX antibody | |
| CD 268 antibody | |
| CD268 antibody | |
| CD268 antigen antibody | |
| CVID4 antibody | |
| MGC138235 antibody | |
| OTTHUMP00000028746 antibody | |
| Prolixin antibody | |
| TNFRSF 13C antibody | |
| Tnfrsf13c antibody | |
| TR13C_HUMAN antibody | |
| Tumor necrosis factor receptor subunit member 13C antibody | |
| Tumor necrosis factor receptor superfamily member 13C antibody |
Target information
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
Provider
Erpantech Laboratory
