Anti-Axin2 antibody
Specifications
| Product Cat#: | AB-06-0436 |
| Product type: | Primary antibody |
| Antigen: | Axin2 |
| Immunogen: | Purified recombinant fragment of human AXIN1 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunocytochemistry/Immunofluorescence (1:100-1:200); Immunohistochemistry (1:10-1:50) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, JM11-30 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Axil antibody |
| Axin like protein antibody | |
| Axin-2 antibody | |
| Axin-like protein antibody | |
| Axin2 antibody | |
| AXIN2_HUMAN antibody | |
| Axis inhibition protein 2 antibody | |
| Conductin antibody | |
| DKFZp781B0869 antibody | |
| MGC10366 antibody | |
| MGC126582 antibody |
Target information
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684).
Provider
Erpantech Laboratory
