Anti-Aurora C antibody
Specifications
| Product Cat#: | AB-06-0426 |
| Product type: | Primary antibody |
| Antigen: | Aurora C |
| Immunogen: | KLH conjugated synthetic peptide derived from human Aurora C 51-150/344 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit |
| Clonality (clone number): | Monoclonal, SC55-08 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | IPL-1/STK13/Aurora C |
| AURKC | |
| AIE2 | |
| AIK3 | |
| AurC | |
| AURKC | |
| Aurora C | |
| Aurora/Ipl1 related kinase 3 | |
| IPL-1 | |
| Aurora/Ipl1/Eg2 protein 2 | |
| EC 2.7.11.1 | |
| Serine threonine protein kinase 13 | |
| STK13 |
Target information
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ‘Ser-10’ and ‘Ser-28’. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at ‘Ser-228’.
Provider
Erpantech Laboratory
