Anti-ATG4A antibody
Specifications
| Product Cat#: | AB-07-0377 |
| Product type: | Primary antibody |
| Antigen: | ATG4A |
| Immunogen: | A synthetic peptide derived from human ATG4A. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunofluorescence (1:100-1:500); ELISA (1:20000); Immunohistochemistry (1:50-1:100) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Cysteine protease ATG4A; EC 3.4.22.-; Autophagy-related protein 4 homolog A; hAPG4A; Autophagin-2; Autophagy-related cysteine endopeptidase 2; AUT-like 2 cysteine endopeptidase |
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Target information
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Provider
Erpantech Laboratory
