Anti-ATG14L antibody
Specifications
| Product Cat#: | AB-06-0401 |
| Product type: | Primary antibody |
| Antigen: | ATG14L |
| Immunogen: | Purified recombinant fragment of human ATG13 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:40-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, C10-F7 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ATG13 antibody |
| ATG13 autophagy related 13 homolog (S. cerevisiae) antibody | |
| ATG13_HUMAN antibody | |
| Autophagy related 13 antibody | |
| Autophagy related protein 13 antibody | |
| Autophagy-related protein 13 antibody | |
| FLJ20698 antibody | |
| KIAA0652 antibody | |
| OTTHUMP00000233321 antibody | |
| OTTHUMP00000233322 antibody | |
| OTTHUMP00000233323 antibody | |
| OTTHUMP00000233324 antibody | |
| OTTHUMP00000233325 antibody | |
| OTTHUMP00000233326 antibody |
Target information
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).
Provider
Erpantech Laboratory
