Anti-ATG13 antibody
Specifications
| Product Cat#: | AB-06-0399 |
| Product type: | Primary antibody |
| Antigen: | ATG13 |
| Immunogen: | This antibody is produced by immunizing rabbits with a synthetic peptide (KLHcoupled) corresponding to ATG12. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:1000); Immunohistochemistry (1:40-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, E12-B2 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ATG13 antibody |
| ATG13 autophagy related 13 homolog (S. cerevisiae) antibody | |
| ATG13_HUMAN antibody | |
| Autophagy related 13 antibody | |
| Autophagy related protein 13 antibody | |
| Autophagy-related protein 13 antibody | |
| FLJ20698 antibody | |
| KIAA0652 antibody | |
| OTTHUMP00000233321 antibody | |
| OTTHUMP00000233322 antibody | |
| OTTHUMP00000233323 antibody | |
| OTTHUMP00000233324 antibody | |
| OTTHUMP00000233325 antibody | |
| OTTHUMP00000233326 antibody |
Target information
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
Provider
Erpantech Laboratory