Anti-ATG12 antibody
Specifications
| Product Cat#: | AB-06-0397 |
| Product type: | Primary antibody |
| Antigen: | ATG12 |
| Immunogen: | Recombinant protein within human Atg12 aa 1-100 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:40-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | APG12-like antibody |
| APG12L antibody | |
| ATG12 antibody | |
| ATG12 autophagy related 12 homolog (S. cerevisiae) antibody | |
| ATG12 autophagy related 12 homolog antibody | |
| ATG12_HUMAN antibody | |
| Autophagy 12 antibody | |
| Autophagy-related protein 12 antibody | |
| FBR93 antibody | |
| HAPG12 antibody |
Target information
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established (PubMed:19666601).
Provider
Erpantech Laboratory
