Anti-ATF4 antibody
Specifications
| Product Cat#: | AB-06-0391 |
| Product type: | Primary antibody |
| Antigen: | ATF4 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000); Immunocytochemistry/Immunofluorescence (1:100-1:200); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:40-1:100); Immunoprecipitation |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, SD20-92 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Activating transcription factor 4 antibody |
| ATF 4 antibody | |
| ATF4 antibody | |
| ATF4 protein antibody | |
| ATF4_HUMAN antibody | |
| cAMP-dependent transcription factor ATF-4 antibody | |
| cAMP-responsive element-binding protein 2 antibody | |
| CREB 2 antibody | |
| CREB-2 antibody | |
| CREB2 antibody | |
| Cyclic AMP dependent transcription factor ATF 4 antibody | |
| Cyclic AMP response element binding protein 2 antibody | |
| Cyclic AMP-dependent transcription factor ATF-4 antibody | |
| Cyclic AMP-responsive element-binding protein 2 antibody | |
| DNA binding protein TAXREB67 antibody | |
| DNA-binding protein TAXREB67 antibody | |
| Tax Responsive Enhancer Element B67 antibody | |
| Tax-responsive enhancer element-binding protein 67 antibody | |
| TaxREB67 antibody | |
| TXREB antibody |
Target information
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AC][AG]-3′), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).
Provider
Erpantech Laboratory
