Anti-ASC antibody
Specifications
| Product Cat#: | AB-07-2394 |
| Product type: | Primary antibody |
| Antigen: | ASC |
| Immunogen: | A synthetic peptide derived from human ASC. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2500); Immunohistochemistry (1:50-1:80); ELISA (1:35000) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Apoptosis-associated speck-like protein containing a CARD, hASC, PYD and CARD domain-containing protein, Target of methylation-induced silencing 1, Caspase recruitment domain-containing protein 5, PYCARD, ASC, CARD5, TMS1 |
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Target information
Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have ‘Lys-63’-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).
Provider
Erpantech Laboratory
