Anti-Aryl Hydrocarbon Receptor antibody
Specifications
| Product Cat#: | AB-06-0376 |
| Product type: | Primary antibody |
| Antigen: | Aryl Hydrocarbon Receptor antibody |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:2000); Immunocytochemistry/Immunofluorescence (1:50-1:500) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, JM34-10 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Ah receptor antibody |
| AhR antibody | |
| AHR_HUMAN antibody | |
| Aromatic hydrocarbon receptor antibody | |
| Aryl hydrocarbon receptor antibody | |
| Aryl hydrocarbon receptor precursor antibody | |
| bHLHe76 antibody | |
| Class E basic helix loop helix protein 76 antibody | |
| Class E basic helix-loop-helix protein 76 antibody | |
| HGNC:348 antibody |
Target information
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Involved in cell-cycle regulation (PubMed:12213388). Likely to play an important role in the development and maturation of many tissues (PubMed:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5′-TGCGTG-3′ within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
Provider
Erpantech Laboratory
