Anti-Aquaporin 4 antibody
Specifications
| Product Cat#: | AB-06-0356 |
| Product type: | Primary antibody |
| Antigen: | Aquaporin-4 |
| Immunogen: | KLH conjugated synthetic peptide derived from human AQP4 271-323/323 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-800); Flow Cytometry (1μg/test) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Aquaporin 4 |
| WCH4 | |
| Mercurial-insensitive water channel | |
| MIWC | |
| AQP 4 | |
| AQP4 | |
| Aquaporin4 | |
| HMIWC 2 | |
| HMIWC2 | |
| Mercurial insensitive water channel | |
| MGC22454 | |
| MIWC | |
| AQP4_HUMAN | |
| Aquaporin-4 |
Target information
Forms a water-specific channel (PubMed:8660998, PubMed:9276712, PubMed:18286643). Plays an important role in brain water homeostasis and in glymphatic solute transport (PubMed:22896675, PubMed:27751903, PubMed:30561329, PubMed:30557661). Required for a normal rate of water exchange across the blood brain interface (PubMed:30557661). Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP (PubMed:22896675, PubMed:27751903, PubMed:30561329). Plays a redundant role in urinary water homeostasis and urinary concentrating ability (PubMed:9276712).
Provider
Erpantech Laboratory
