Anti-APC antibody
Specifications
| Product Cat#: | AB-06-0323 |
| Product type: | Primary antibody |
| Antigen: | APC |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-5000); Immunocytochemistry (1:100-1:200); Immunoprecipitation |
| Reactivity: | Rat and Human |
| Clonality (clone number): | Monoclonal, SC61-03 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Adenomatous Polyposis Coli antibody |
| Adenomatous polyposis coli protein antibody | |
| Apc antibody | |
| APC_HUMAN antibody | |
| CC1 antibody | |
| Deleted in polyposis 2.5 antibody | |
| DP2 antibody | |
| DP2.5 antibody | |
| DP3 antibody | |
| FAP antibody | |
| FPC antibody | |
| GS antibody | |
| Protein APC antibody |
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Target information
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Provider
Erpantech Laboratory