Anti-AMID antibody
Specifications
| Product Cat#: | AB-06-4798 |
| Product type: | Primary antibody |
| Antigen: | AMID |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human AIFM2. AA range:141-190 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | WB (1:500-1:2000); Immunohistochemistry-Paraffin (1:150-300) ; Immunofluorescence (1:200-1:500) |
| Reactivity: | Human, Mouse, Monkey |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS (pH7.4), 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Concentration: | 1 mg/ml |
| Purity: | Immunogen affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Non-conjugated |
| Alternative names: | AIFM2 antibody; AMID antibody; PRG3 antibody; Apoptosis-inducing factor 2 antibody; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death antibody; Apoptosis-inducing factor-like mitochondrion-associated inducer of death antibody; p53-responsive gene 3 protein antibody |
Target information
A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels (PubMed:31634899, PubMed:31634900). May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death (PubMed:26689472). Capable of DNA binding in a non-sequence specific way (PubMed:15958387).
Provider
Erpantech Laboratory
