Anti-Alpha-Synuclein antibody
Specifications
| Product Cat#: | AB-06-0268 |
| Product type: | Primary antibody |
| Antigen: | Alpha-ENaC |
| Species immunized: | Mouse |
| Immunogen: | Amino acids 121-125 of α-synuclein of human origin. |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:200-1000); Immunoprecipitation (1-2 μg per 100-500 μg of total protein); Immunofluorescence (1:100-500) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, 2G5 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Alpha synuclein antibody |
| Alpha-synuclein antibody | |
| Alpha-synuclein, isoform NACP140 antibody | |
| AlphaSYN antibody | |
| MGC105443 antibody | |
| MGC110988 antibody | |
| MGC127560 antibody | |
| MGC64356 antibody | |
| NACP antibody | |
| Non A beta component of AD amyloid antibody | |
| Non A4 component of amyloid antibody | |
| Non A4 component of amyloid precursor antibody | |
| Non-A beta component of AD amyloid antibody | |
| Non-A-beta component of alzheimers disease amyloid , precursor of antibody |
Target information
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).
Provider
Erpantech Laboratory