Anti-ALDH2 Mouse Monoclonal antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | ALDH2 |
| Immunogen: | This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to the sequence of human ALDH2. |
| Species immunized: | Mouse |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunocytochemistry (1:50-1:200); Immunohistochemistry (1:100-1:500) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal, 7-D8 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Acetaldehyde dehydrogenase 2 antibody |
| Aldehyde dehydrogenase 2 family (mitochondrial) antibody | |
| Aldehyde dehydrogenase 2 family antibody | |
| Aldehyde dehydrogenase mitochondrial antibody | |
| Aldehyde dehydrogenase, mitochondrial antibody |
Target information
Aldehyde dehydrogenase 2 family (mitochondrial), also known as ALDH2, is a human gene found on chromosome 12. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. The ALDH2 gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Most Europeans have two major isozymes, while approximately 50% of Northeast Asians have one normal copy of the ALDH2 gene and one mutant copy that encodes an inactive mitochondrial isoenzyme. A remarkably higher frequency of acute alcohol intoxication among Northeast Asians than among Europeans has been repeatedly shown to be related to the very much reduced activity of the mutant ALDH2-2 isoenzyme.
Provider
Erpantech Laboratory