Anti-AIM2 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | AIM2 |
| Immunogen: | Purified recombinant fragment of human AIM2 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000); Immunocytochemistry (1:100-1:200); Flow Cytometry (1:100-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, 4G-11 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Absent in melanoma 2 antibody |
| AIM 2 antibody | |
| Aim2 antibody | |
| AIM2_HUMAN antibody | |
| Interferon-inducible protein AIM2 antibody |
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Target information
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Provider
Erpantech Laboratory