Anti-ADAMTS5 antibody
Specifications
| Product Cat#: | AB-06-0154 |
| Product type: | Primary antibody |
| Antigen: | ADAMTS5 |
| Immunogen: | KLH conjugated synthetic peptide derived from human Aggrecan 2 511-610/930 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-800) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ADAMTS5 |
| A disintegrin and metalloproteinase with thrombospondin motifs 5 | |
| A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5 | |
| A Disintigrin And Metalloproteinase with ThromboSpondin motif-5 |
Target information
Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan . Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.
Provider
Erpantech Laboratory
