Anti-ADAM17 antibody
Specifications
| Product Cat#: | AB-06-0146 |
| Product type: | Primary antibody |
| Antigen: | ADAM17 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunocytochemistry/Immunofluorescence (1:100-1:200); Flow Cytometry (1:25-1:100); Immunoprecipitation (1:50) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal, JM10-35 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) antibody |
| A disintegrin and metalloproteinase domain 17 antibody | |
| ADA17_HUMAN antibody | |
| ADAM 17 antibody |
Target information
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form . Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface . Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein . Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) . Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity).
Provider
Erpantech Laboratory