Anti-ADAM10 antibody
Specifications
| Product Cat#: | AB-06-0142 |
| Product type: | Primary antibody |
| Antigen: | ADAM10 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000); Immunoprecipitation (1:20-50) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal, JM32-11 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified/Antigen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | A disintegrin and metalloprotease domain 10 antibody |
| AD 10 antibody | |
| AD18 antibody |
Target information
Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77′ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface . Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) . Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity . Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). May regulate the EFNA5-EPHA3 signaling .
Provider
Erpantech Laboratory
