Anti-ADAM10 antibody

Target information

Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77′ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface . Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) . Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity . Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). May regulate the EFNA5-EPHA3 signaling .