Anti-5HT2B Receptor antibody

target information

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) . Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and downstream signaling cascades and promotes the release of Ca²⁺ ions from intracellular stores (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity . May play a role in the perception of pain . Plays a role in the regulation of behavior, including impulsive behavior . Required for normal proliferation of embryonic cardiac myocytes and normal heart development . Protects cardiomyocytes against apoptosis . Plays a role in the adaptation of pulmonary arteries to chronic hypoxia . Plays a role in vasoconstriction . Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine .