Anti-53BP1 antibody
Specifications
| Product Cat#: | AB-06-0089 |
| Product type: | Primary antibody |
| Antigen: | 53BP1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Flow Cytometry(1:25-100); Immunohistochemistry(1:100-200); Western Blot(1:250-1000); Immunocytochemistry/Immunofluorescence (1:100-250) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal, JA66-11 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 53 BP1 antibody |
| 53BP1 antibody | |
| FLJ41424 antibody | |
| MGC138366 antibody | |
| P202 antibody | |
| P53 binding protein 1 antibody | |
| P53 BP1 antibody | |
| P53-binding protein 1 antibody | |
| P53BP1 antibody | |
| TP53 BP1 antibody | |
| TP53B_HUMAN antibody | |
| Tp53bp1 antibody | |
| TRP53 BP1 antibody | |
| Tumor protein 53 binding protein 1 antibody | |
| Tumor protein p53 binding protein 1 antibody | |
| Tumor suppressor p53 binding protein 1 antibody | |
| Tumor suppressor p53-binding protein 1 antibody |
Target information
Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis . Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 . In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites . Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at ‘Lys-15’ (H2AK15Ub) and histone H4 dimethylated at ‘Lys-20’ (H4K20me2), two histone marks that are present at DSBs sites . Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs . Participates to the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 .
Provider
Erpantech Laboratory
