Anti-Caspase 3 (Cleaved-Asp175) antibody
Specifications
| Product Cat#: | AB-07-0241 |
| Product type: | Primary antibody |
| Antigen: | Caspase 3 (Cleaved-Asp175) |
| Immunogen: | A synthetic peptide derived from human Caspase 3. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500~1:3000); ELISA (1:20000); Immunohistochemistry (1:50~1:100) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Apopain; CASP-3; Caspase-3; CPP-32; CPP32; Cysteine protease CPP32; EC 3.4.22.56; ICE3; SCA-1; SREBP cleavage activity 1; Yama |
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Target information
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ‘216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Provider
Erpantech Laboratory
