Anti-p21-ARC antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | p21-ARC |
| Immunogen: | KLH conjugated synthetic peptide derived from human p21-ARC 2-100/178 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:2000) |
| Reactivity: | Human, Mouse, Rat, Chicken, Cow, Rabbit, Xenopus laevis |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Actin related protein 2/3 complex subunit 3 |
| ARC21 | |
| ARPC3_HUMAN | |
| ARP2/3 complex 21 kDa subunit | |
| ARP2/3 protein complex subunit p21 |
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Target information
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Provider
Erpantech Laboratory
