Anti-NMDAR2C antibody
Specifications
| Product Cat#: | AB-06-3159 |
| Product type: | Primary antibody |
| Antigen: | NMDAR2C |
| Immunogen: | KLH conjugated synthetic peptide derived from human NMDAR2C 501-600/1482 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | NR2C |
| N-Methyl-d-Asprtate receptor 2C | |
| Glutamate Receptor Ionotropic N Methyl D Aspartate 2C | |
| GRIN2C | |
| N Methly D Aspartate Receptor Channel Subunit Epsilon 3 | |
| N Methyl D Aspartate Receptor Subtype 2C | |
| NR2C |
Target information
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).
Provider
Erpantech Laboratory