Anti-BLK antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | BLK |
| Immunogen: | Purified recombinant fragment of human BLK expressed in E. Coli |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:1000); Immunocytochemistry (1:100-1:500); Flow Cytometry (1:100-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, A5-E6 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified/Antigen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | B lymphocyte kinase antibody |
| B lymphoid tyrosine kinase antibody | |
| Blk antibody | |
| BLK nonreceptor tyrosine kinase antibody | |
| BLK_HUMAN antibody | |
| EC 2.7.10.2 antibody | |
| MGC 10442 antibody | |
| MGC10442 antibody | |
| MODY 11 antibody | |
| MODY11 antibody | |
| P55 BLK antibody | |
| p55-BLK antibody | |
| Tyrosine kinase B lymphocyte specific antibody | |
| Tyrosine protein kinase antibody | |
| Tyrosine-protein kinase BLK antibody |
Target information
Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at ‘Tyr-188’and ‘Tyr-199’, as well as CD79B at ‘Tyr-196’ and ‘Tyr-207’ (By similarity). Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214).
Provider
Erpantech Laboratory
