Anti-BAX antibody
Specifications
| Product Cat#: | AB-06-0464 |
| Product type: | Primary antibody |
| Antigen: | BAX |
| Immunogen: | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to N-terminal BAX. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:1000); Immunohistochemistry (1:100-1:200); Immunocytochemistry (1:100-1:200) |
| Reactivity: | Mouse, Human, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Apoptosis regulator BAX antibody |
| BAX antibody | |
| Bax-protein antibody | |
| BAX_HUMAN antibody | |
| BAXA antibody | |
| Baxdelta2G9 antibody | |
| Baxdelta2G9omega antibody | |
| Baxdelta2omega antibody | |
| Bcl-2-like protein 4 antibody | |
| BCL2 associated X protein antibody | |
| BCL2 associated X protein omega antibody | |
| BCL2 associated X protein transcript variant delta2 antibody | |
| Bcl2-L-4 antibody | |
| BCL2L4 antibody | |
| Membrane isoform alpha antibody |
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Target information
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Provider
Erpantech Laboratory