Anti-ERO1L antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | ERO1L |
| Immunogen: | KLH conjugated synthetic peptide derived from human ERO1L 321-420/468 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000) |
| Reactivity: | Human, Mouse, Rat, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified/Antigen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Endoplasmic oxidoreductin 1 like protein |
| Endoplasmic oxidoreductin-1-like protein | |
| ERO1 alpha | |
| ERO1 L | |
| ERO1 Lalpha | |
| ERO1 like protein alpha | |
| ERO1-L | |
| ERO1-L-alpha | |
| ERO1-like (S. cerevisiae) | |
| ERO1-like protein alpha | |
| ERO1A | |
| ERO1A_HUMAN | |
| ERO1L | |
| Oxidoreductin 1 Lalpha |
Target information
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
Provider
Erpantech Laboratory
