Anti-ERN1 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | ERN1 |
| Immunogen: | Purified recombinant fragment of human ERN1 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:200-1:2000);Immunohistochemistry (1:50-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal（C9-F2） |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% |
| Concentration: | 1mg/ml |
| Purity: | ProA affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Endoplasmic reticulum (ER) to nucleus signalling 1 antibody |
| Endoplasmic reticulum to nucleus signaling 1 antibody | |
| Endoplasmic reticulum-to-nucleus signaling 1 antibody | |
| Endoribonuclease antibody | |
| ER to nucleus signaling 1 antibody | |
| ERN 1 antibody | |
| Ern1 antibody | |
| ERN1_HUMAN antibody | |
| hIRE 1p antibody | |
| hIRE1p antibody | |
| Inositol requiring 1 antibody | |
| Inositol requiring 1, S. cerevisiae, homolog of antibody | |
| Inositol requiring enzyme 1, S. cerevisiae, homolog of antibody | |
| Inositol requiring protein 1 antibody | |
| inositol-requiring enzyme 1 antibody | |
| Inositol-requiring protein 1 antibody | |
| IRE 1 antibody | |
| IRE 1a antibody | |
| IRE 1P antibody | |
| Ire1 alpha antibody | |
| Ire1-alpha antibody | |
| IRE1a antibody | |
| Ire1alpha antibody | |
| IRE1P antibody | |
| MGC163277 antibody | |
| MGC163279 antibody | |
| Protein kinase/endoribonuclease antibody | |
| RGD1559716 antibody | |
| Serine/threonine protein kinase/endoribonuclease IRE1 antibody |
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Target information
Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity
Provider
Erpantech Laboratory
