Human Androgen Receptor ELISA kit
Specifications
| Product Cat#: | EK-07-0187 |
| Product name: | Human Androgen Receptor ELISA kit |
| Target Name: | AR |
| Species Reactivity: | Human |
| Product Size: | 48/96 Tests |
| Sensitivity: | 1.4 pg/mL |
| Assay range: | 10-250 pg/mL |
| Assay Time: | 90 minutes |
| Platform: | Colorimetric Microplate Reader |
| Conjugate: | HRP |
| ELISA Type: | Competitive ELISA |
| Detection Method: | Colorimetric |
| Storage temperature: | Store at 2-8°C |
| Stability: | Stable within the expiration date under suggested storage conditions |
| Shipping condition: | Wet ice |
| Kit Contents: | Microtiter plate ( 1x ), Enzyme conjugate ( 1 vial ), Standard samples ( 6 vials ), |
| Substrates ( A & B, 2 vials ), Stop solution ( 1 vial ), Wash Solution ( 100x, 1 vial ), | |
| Balance solution ( 1 vial ), Instruction ( 1 copy ) | |
| Other Names of Target: | Androgen Receptor Isoform 2; AIS; AIS; ANDR; Androgen Receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease); Androgen Receptor; AR; DHTR; Dihydro Testosterone Receptor; Dihydrotestosterone Receptor; HUMARA; HYSP1; HYSP1; KD; NR3C4; Nuclear Receptor Subfamily 3 group C Member 4; SBMA; SMAX1; Spinal and Bulbar Muscular Atrophy; TFM; AR |
Target information
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Provider
Erpantech Laboratory
