Anti-Arginase II antibody
Specifications
| Product Cat#: | AB-06-0366 |
| Product type: | Primary antibody |
| Antigen: | Arginase II |
| Immunogen: | KLH conjugated synthetic peptide derived from human Arginase II 181-290/354 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-800); Immunocytochemistry (1:50-1:500); Immunofluorescence (1:50-500) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ARG 2 |
| ARG2 | |
| ARGI2_HUMAN | |
| Arginase-2 | |
| Arginase 2 | |
| Arginase liver | |
| Arginase type II | |
| Arginase II | |
| ArginaseII | |
| Arginase-II | |
| Arginase1 | |
| Arginase-2, mitochondrial | |
| Kidney-type arginase | |
| Non-hepatic arginase | |
| Type II arginase |
Target information
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4+ and CD8+ T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189).
Provider
Erpantech Laboratory
