Anti-APPBP1 antibody
Specifications
| Product Cat#: | AB-06-0351 |
| Product type: | Primary antibody |
| Antigen: | APPBP1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human APPBP1 401-500/534 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | A 116A10.1 |
| Amyloid beta precursor protein binding protein 1 59kD | |
| Amyloid beta precursor protein binding protein 1 59kDa | |
| Amyloid beta precursor protein binding protein 1 | |
| Amyloid beta precursor protein-binding protein 1 | |
| Amyloid protein binding protein 1 | |
| Amyloid protein-binding protein 1 | |
| APP BP1 | |
| APP-BP1 | |
| APPBP 1 | |
| HPP 1 | |
| HPP1 | |
| NAE 1 | |
| NAE1 | |
| NEDD8 activating enzyme E1 regulatory subunit | |
| NEDD8 activating enzyme E1 subunit 1 | |
| NEDD8 activating enzyme E1 subunit | |
| NEDD8-activating enzyme E1 regulatory subunit | |
| Proto oncogene protein 1 | |
| Proto-oncogene protein 1 | |
| Protooncogene protein 1 | |
| Ula 1 |
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Target information
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Provider
Erpantech Laboratory
