Anti-SUN1 antibody
Specifications
| Product Cat#: | AB-06-4234 |
| Product type: | Primary antibody |
| Antigen: | SUN1 |
| Immunogen: | Recombinant protein corresponding to C-terminal human SUN1. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:600-1:2000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:60-1:200); Flow Cytometry (1:40-1:100) |
| Reactivity: | Human, Rat |
| Clonality (clone number): | Monoclonal (JG95-31) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Protein unc-84 homolog A antibody |
| Sad1 and UNC84 domain containing 1 antibody | |
| Sad1/unc 84 protein like 1 antibody | |
| Sad1/unc-84 protein-like 1 antibody | |
| Sun domain-containing protein 1 antibody | |
| Sun1 antibody | |
| SUN1_HUMAN antibody | |
| UNC 84 homolog A (C elegans) antibody | |
| UNC 84A antibody | |
| UNC84 A antibody | |
| UNC84 antibody | |
| UNC84 homolog A (C elegans) antibody | |
| UNC84A antibody |
Target information
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenenis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links.
Provider
Erpantech Laboratory