Anti-STAT3 antibody
Specifications
| Product Cat#: | AB-06-4203 |
| Product type: | Primary antibody |
| Antigen: | STAT3 |
| Immunogen: | Recombinant protein. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunofluorescence; Western Blot (1:900-1:2000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:200-1:500) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal (SY34-01) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 1110034C02Rik antibody |
| Acute Phase Response Factor antibody | |
| Acute-phase response factor antibody | |
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| FLJ20882 antibody | |
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| Signal transducer and activator of transcription 3 (acute phase response factor) antibody | |
| Signal transducer and activator of transcription 3 antibody | |
| STAT 3 antibody | |
| Stat3 antibody |
Target information
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors . Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene . May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 . Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA . Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity . Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 . Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation . Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity . Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).
Provider
Erpantech Laboratory