Anti-EZH1 antibody
Specifications
| Product cat: | AB-06-1626 |
| Product type: | Primary antibody |
| Antigen: | EZH1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human EZH1 471-510/747 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:900-1:2400); Immunohistochemistry-Paraffin (1:400-900) |
| Reactivity: | Mouse,Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig, Rat and Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 50% glycerol,0.03% Proclin300, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Enhancer of zeste homolog 1(Drosophila) |
| Enhancer of zeste homolog 1 | |
| ENX-2 | |
| ENX2 | |
| EZH1 | |
| EZH1: enhancer of zeste homolog 1 (Drosophila) | |
| EZH1_HUMAN | |
| Histone-lysine N-methyltransferase EZH1 |
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Target information
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates ‘Lys-27’ of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate ‘Lys-27’ of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Provider
Erpantech Laboratory