Anti-SMURF 2 antibody
Specifications
| Product cat: | AB-06-4130 |
| Product type: | Primary antibody |
| Antigen: | SMURF 2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:900-1:2400) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JU32-34) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | E3 ubiquitin-protein ligase SMURF2 antibody |
| EC 6.3.2. antibody | |
| hSMURF2 antibody | |
| MGC138150 antibody | |
| Smad specific E3 ubiquitin ligase 2 antibody | |
| SMAD specific E3 ubiquitin protein ligase 2 antibody | |
| SMAD ubiquitination regulatory factor 2 antibody | |
| SMAD-specific E3 ubiquitin-protein ligase 2 antibody | |
| SMUF2_HUMAN antibody | |
| Smurf2 antibody | |
| Ubiquitin protein ligase SMURF2 antibody |
Target information
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Provider
Erpantech Laboratory