Anti-Phospho-PAK1 (S144)+PAK2 (S141)+PAK3 (S139) antibody
Specifications
| Product Cat#: | AB-06-3529 |
| Product type: | Primary antibody |
| Antigen: | Phospho-PAK1(S144)+PAK2(S141)+PAK3(S139) |
| Immunogen: | Synthetic phospho-peptide corresponding to residues surrounding Ser144 of human PAK1. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:900-1:2000); Immunohistochemistry (1:40-1:200); Immunocytochemistry (1:40-1:200); Flow Cytometry (1:40-1:100); Immunoprecipitation; Immunofluorescence |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (SU03-70) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA; 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 暂无信息 |
Target information
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.
Provider
Erpantech Laboratory
