Anti-Smad3 antibody
Specifications
| Product Cat#: | AB-06-4116 |
| Product type: | Primary antibody |
| Antigen: | Smad3 |
| Immunogen: | Peptide |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot ( 1:300-1:1000 ); Immunoprecipitation ( 1-3 μg per 100-500 μg of total protein ( 1 ml of cell lysate ) ); Immunohistochemistry ( 1:30-1:500 ); Immunohistochemistry ( 1:80-1:500 ) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal ( 80 ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DKFZP586N0721 Antibody |
| DKFZp686J10186 Antibody | |
| hMAD 3 Antibody | |
| hMAD-3 Antibody | |
| hSMAD3 Antibody | |
| HSPC193 Antibody | |
| HST17436 Antibody | |
| JV15 2 Antibody | |
| JV15-2 Antibody | |
| JV152 Antibody | |
| LDS1C Antibody | |
| LDS3 Antibody | |
| MAD (Mothers Against Decapentaplegic Drosophila) Homolog 3 Antibody | |
| MAD Homolog 3 Antibody | |
| Mad Homolog JV15 2 Antibody | |
| Mad Protein Homolog Antibody | |
| MAD, MothersAgainstDecapentaplegic Homolog 3 Antibody | |
| Mad3 Antibody | |
| MADH 3 Antibody | |
| MADH3 Antibody | |
| MGC60396 Antibody | |
| Mothers Against Decapentaplegic Homolog 3 Antibody | |
| Mothers Against DPP Homolog 3 Antibody | |
| SMA and MAD Related Protein 3 Antibody | |
| SMAD 3 Antibody | |
| SMADAntibody | |
| SMAD Family Member 3 Antibody | |
| SMAD, Mothers Against DPP Homolog 3 Antibody | |
| Smad3 Antibody | |
| SMAD3_HUMAN Antibody |
Target information
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Provider
Erpantech Laboratory
