Anti-PTEN antibody
Specifications
| Product Cat#: | AB-06-3747 |
| Product type: | Primary antibody |
| Antigen: | PTEN |
| Immunogen: | Peptide raised against the C-terminus of PTEN of human origin. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:1000); Immunoprecipitation(1-2 μg per 100-500 μg of total protein); Immunofluorescence (1:60-1:500) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal (4D8) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 10q23del antibody |
| BZS antibody | |
| DEC antibody | |
| GLM2 antibody | |
| MGC11227 antibody | |
| MHAM antibody | |
| MMAC1 antibody | |
| MMAC1 phosphatase and tensin homolog deleted on chromosome 10 antibody | |
| Mutated in multiple advanced cancers 1 antibody | |
| Phosphatase and tensin homolog antibody | |
| Phosphatase and tensin like protein antibody | |
| Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN antibody | |
| Pten antibody | |
| PTEN_HUMAN antibody |
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Target information
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226, PubMed:16824732). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.2 Publications
Isoform alpha: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.
Provider
Erpantech Laboratory
