Anti-Phospho-Smad2 (S250) antibody
Specifications
| Product Cat#: | AB-06-3553 | |
| Product type: | Primary antibody | |
| Antigen: | Phospho-Smad2 (S250) | |
| Immunogen: | Synthetic phospho-peptide corresponding to residues surrounding Ser250 of human Smad2 | |
| Species immunized: | Rabbit | |
| Isotype: | IgG | |
| Applications: | Western Blot (1:1000); Flow Cytometry (1:50-1:100) | |
| Reactivity: | Human, Mouse, Rat | |
| Clonality (clone number): | Monoclonal (SD207-1) | |
| Form: | Liquid | |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. | |
| Concentration: | 1 mg/ml | |
| Purity: | Protein A affinity purified | |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. | |
| Alternative names: | Drosophila, homolog of, MADR2 antibody | |
| hMAD-2 antibody | ||
| HsMAD2 antibody | ||
| JV18 antibody | ||
| JV18-1 antibody | ||
| JV181 antibody | ||
| MAD antibody | ||
| MAD homolog 2 antibody | ||
| MAD Related Protein 2 antibody | ||
| Mad-related protein 2 antibody | ||
| MADH2 antibody | ||
| MADR2 antibody | ||
| MGC22139 antibody | ||
| MGC34440 antibody | ||
| Mother against DPP homolog 2 antibody | ||
| Mothers against decapentaplegic homolog 2 antibody | ||
| Mothers against decapentaplegic, Drosophila, homolog of, 2 antibody | ||
| Mothers against DPP homolog 2 antibody | ||
| OTTHUMP00000163489 antibody | ||
| Sma and Mad related protein 2 antibody | ||
| Sma- and Mad-related protein 2 MAD antibody | ||
| SMAD 2 antibody | ||
| SMAD family member 2 antibody | ||
| SMAD, mothers against DPP homolog 2 antibody | ||
| SMAD2 antibody | ||
| SMAD2_HUMAN antibody |
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Target information
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Provider
Erpantech Laboratory
