Anti-SIRT3 antibody
Specifications
| Product Cat#: | AB-06-4067 |
| Product type: | Primary antibody |
| Antigen: | SIRT3 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:400-1:1000 ): Flow Cytometry ( 1:80-1:200 ) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal ( 2A-1B ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | hSIRT 3 Antibody |
| hSIRT3 Antibody | |
| Mitochondrial Nicotinamide Adenine Dinucleotide Dependent Deacetylase Antibody | |
| NAD Dependent Deacetylase Sirtuin 3 Mitochondrial Antibody | |
| NAD-dependent Protein Deacetylase Sirtuin-3, Mitochondrial Antibody | |
| Regulatory Protein SIR2 Homolog 3 Antibody | |
| Silent Mating Type Information Regulation 2 S.cerevisiae Homolog 3 Antibody | |
| Sir 2 Like 3 Antibody | |
| SIR 2 Like protein 3Antibody | |
| SIR 3 Antibody | |
| SIR2 L3 Antibody | |
| Sir2 Like 3 Antibody | |
| SIR2 Like Protein 3 Antibody | |
| SIR2-like Protein 3 Antibody | |
| SIR2L3 Antibody | |
| SIR3_HUMAN Antibody | |
| SIRT 3 Antibody | |
| SIRT3 Antibody | |
| Sirtuin 3 Antibody | |
| Sirtuin Silent Mating Type Information Regulation 2 Homolog 3 (S. cerevisiae) Antibody |
Target information
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologues, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT3 is a NAD-dependent deacetylase that contains one deacetylase sirtuin-type domain. The SIRT3 protein is widely expressed and localizes to the mitochondira where it is processed by mitochondrial processing peptidase (MPP) to yield a final product. This processing is most-likely necessary for its enzymatic activity.
Provider
Erpantech Laboratory