Anti-Protein FAM38A antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Protein FAM38A |
| Immunogen: | Recombinant protein. |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Western Blot (1:600-1:2000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:60-1:200) |
| Reactivity: | Mouse, Human |
| Clonality (clone number): | Monoclonal (2-10) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 2mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DHS |
| Fam38a | |
| Family with sequence similarity 38 member A | |
| KIAA0233 | |
| Membrane protein induced by beta-amyloid treatment | |
| Mib | |
| PIEZ1_HUMAN | |
| Piezo-type mechanosensitive ion channel component 1 | |
| PIEZO1 | |
| Protein FAM38A | |
| Protein FAM38B | |
| Protein PIEZO1 |
Target information
Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).
Provider
Erpantech Laboratory