Anti-PODXL antibody
Specifications
| Product Cat#: | AB-06-3638 |
| Product type: | Primary antibody |
| Antigen: | PODXL |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Immunocytochemistry (1:200-1:500) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (2-A4) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 2 mg/ml |
| Purity: | Protein G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | GCTM-2 Antigen antibody |
| Gp2 antibody | |
| Gp200 antibody | |
| MGC138240 antibody | |
| PC antibody | |
| PCLP antibody | |
| PCLP-1 antibody | |
| PCLP1 antibody | |
| Pcx antibody | |
| Podocalyxin antibody | |
| Podocalyxin Like antibody | |
| Podocalyxin Like Protein antibody | |
| Podocalyxin-Like Protein 1 antibody | |
| Podxl antibody | |
| PODXL_HUMAN antibody |
Target information
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Provider
Erpantech Laboratory
