Anti-SHIP antibody
Specifications
| Product Cat#: | AB-06-4045 |
| Product type: | Primary antibody |
| Antigen: | SHIP |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:300-1:1000 ); Immunoprecipitation; Immunohistochemistry ( 1:30-1:100 ); Flow Cytometry ( 1:30-1:200 ) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal ( SY11-08 ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Inositol Polyphosphate 5 Phosphatase of 145kDa Antibody |
| 4 Antibody | |
| 5-trisphosphate 5-phosphatase 1 Antibody | |
| hp51CN Antibody | |
| Inositol Polyphosphate 5 Phosphatase 145kDa Antibody | |
| Inositol Polyphosphate 5 Phosphatase Antibody | |
| Inositol Polyphosphate-5-phosphatase of 145 kDa Antibody | |
| INPP5D Antibody | |
| MGC104855 Antibody | |
| MGC142140 Antibody | |
| MGC142142 Antibody | |
| p150Ship Antibody | |
| Phosphatidylinositol 3,4,5 Trisphosphate 5 Phosphatase 1Antibody | |
| Phosphatidylinositol-3 Antibody | |
| SH2 Containing Inositol Phosphatase Isoform b Antibody | |
| SH2 Domain containing Inositol 5' phosphatase 1Antibody | |
| SH2 Domain containing Inositol Phosphatase 1 Antibody | |
| SH2 Domain-containing Inositol Phosphatase 1 Antibody | |
| SH2 Domain-containing Inositol-5"-phosphatase 1 Antibody | |
| SHIP-1 Antibody | |
| SHIP1 Antibody | |
| SHIP1_HUMAN Antibody | |
| Signaling Inositol Polyphosphate 5 Phosphatase SIP 145 Antibody | |
| SIP-145 Antibody | |
| SIP145 Antibody |
Target information
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways .Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression.
Provider
Erpantech Laboratory
