Anti-CD31/PECAM-1 Mouse Monoclonal antibody
Specifications
| Product Cat#: | AB-06-0901 |
| Product type: | Primary antibody |
| Antigen: | CD31/PECAM-1 |
| Immunogen: | Synthetic peptide (KLH-coupled) within C-terminal residues of human CD31. |
| Molecular weight: | Predicted band size: 83 kDa, Observed band size: 130 kDa |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Western Blot ( 1:500-1:5000 ); Immunohistochemistry-Paraffin ( 1:400-1:2000 ); Immunocytochemistry/Immunofluorescence ( 1:50-1:200 ); Flow Cytometry ( 1:50-1:100 ) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal ( 7-A1 ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 0.2% BSA, 50 % glycerol, 0.05 % NaN3. |
| Concentration: | 2 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Adhesion Molecule Antibody |
| CD31 Antibody | |
| CD31 Antigen Antibody | |
| CD31 EndoCAM Antibody | |
| EndoCAM Antibody | |
| FLJ34100 Antibody | |
| FLJ58394 Antibody | |
| GPIIA Antibody | |
| GPIIA' Antibody | |
| PECA1 Antibody | |
| PECA1_HUMAN Antibody | |
| Pecam 1 Antibody | |
| PECAM 1 CD31 EndoCAM Antibody | |
| PECAM Antibody | |
| PECAM-1 Antibody | |
| Pecam1 Antibody | |
| Platelet and Endothelial Cell Adhesion Molecule 1 Antibody | |
| Platelet Endothelial Cell Adhesion Molecule Antibody | |
| Platelet/Endothelial Cell Adhesion Molecule 1 Antibody |
Target information
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils . Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis (By similarity).
Provider
Erpantech Laboratory
