Anti-USP7 antibody (KO Validated)
Specifications
| Product Cat#: | AB-06-4562 |
| Product type: | Primary antibody |
| Antigen: | USP7 |
| Immunogen: | Recombinant protein within Human USP7 aa 80-180/1,102. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:1000); Immunohistochemistry-Paraffin (1:40); Flow Cytometry (1:40-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JB80-36) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 0.05% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Deubiquitinating enzyme 7 antibody |
| HAUSP antibody | |
| Herpes virus associated ubiquitin specific protease antibody | |
| Herpesvirus-associated ubiquitin-specific protease antibody | |
| TEF 1 antibody | |
| Tef-1 antibody | |
| TEF1 antibody | |
| Ubiquitin carboxyl terminal hydrolase 7 antibody | |
| Ubiquitin carboxyl-terminal hydrolase 7 antibody | |
| Ubiquitin specific peptidase 7 (herpes virus associated) antibody | |
| Ubiquitin specific peptidase 7 antibody | |
| Ubiquitin specific peptidase 7 herpes virus associated antibody | |
| Ubiquitin specific processing protease 7 antibody | |
| Ubiquitin specific protease 7 (herpes virus associated) antibody | |
| Ubiquitin specific protease 7 antibody | |
| Ubiquitin specific protease 7 herpes virus associated antibody | |
| Ubiquitin thioesterase 7 antibody | |
| Ubiquitin thiolesterase 7 antibody | |
| Ubiquitin-specific-processing protease 7 antibody | |
| UBP 7 antibody | |
| UBP-7 antibody | |
| UBP7 antibody | |
| UBP7_HUMAN antibody | |
| USP 7 antibody | |
| Usp-7 antibody | |
| Usp7 antibody | |
| VMW110-ASSOCIATED PROTEIN, 135-KD antibody |
Target information
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis . Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis . Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML . Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation.
Provider
Erpantech Laboratory
