Anti-UFD1L antibody
Specifications
| Product Cat#: | AB-06-4531 |
| Product type: | Primary antibody |
| Antigen: | UFD1L |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG2b |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:40-1:200); Flow Cytometry (1:40-1:200); Immunocytochemistry (1:40-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (F3-A6) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | UB fusion protein 1 antibody |
| Ubiquitin fusion degradation 1 like (yeast) antibody | |
| Ubiquitin fusion degradation 1 like antibody | |
| Ubiquitin fusion degradation protein 1 homolog antibody | |
| UFD1 antibody | |
| UFD1_HUMAN antibody | |
| UFD1L antibody |
Target information
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I.
Provider
Erpantech Laboratory