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Anti-CSNK2A2 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-1181
Anti-CSNK2A2 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-1181
Product type: Primary antibody
Antigen: CSNK2A2
Immunogen: Recombinant protein
Species immunized: Mouse
Isotype: IgG1
Applications: Western Blot (1:500-1:1000); Flow Cytometry (1:100-1:200)
Reactivity: Human, Mouse, Rat
Clonality (clone number): Monoclonal (A10-E1)
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 0.05% NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: Casein kinase 2 alpha prime polypeptide antibody
Casein kinase II alpha' chain antibody
Casein kinase II subunit alpha' antibody
CK II alpha' antibody
CK II antibody
CK2A2 antibody
CKII antibody
CSK22_HUMAN antibody
CSNK2A1 antibody
CSNK2A2 antibody
FLJ43934 antibody
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Target information

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating ‘Ser-392’ of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

Provider

Erpantech Laboratory

download

MSDS-AB-06-1181.pdf (125 downloads)